Role of the Kidneys in Formation of Erythropoietin

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In
the normal person, about 90 per cent of all erythro-
poietin is formed in the kidneys; the remainder is
formed mainly in the liver. It is not known exactly
where in the kidneys the erythropoietin is formed.
One likely possibility is that the renal tubular epithe-
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lial cells secrete the erythropoietin, because anemic
blood is unable to deliver enough oxygen from the
peritubular capillaries to the highly oxygen-consuming
tubular cells, thus stimulating erythropoietin pro-
duction.







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